What is the recommended treatment for Lyme Disease in adults?

Doxycycline is the recommended first-line treatment for Lyme disease in adults due to its effectiveness against the causative agent, Borrelia burgdorferi. This antibiotic is particularly beneficial because it can penetrate well into the central nervous system, making it appropriate for neurological manifestations of Lyme disease. Additionally, doxycycline is usually administered for a typical duration of 10 to 21 days, adequately addressing the infection while minimizing the risk of side effects associated with longer antibiotic regimens.

Amoxicillin is sometimes used, especially in children or pregnant women, but doxycycline is generally preferred in adults. Ceftriaxone is reserved for more severe cases, such as those with neurological involvement or when oral antibiotics are not an option. Clindamycin is not typically indicated for Lyme disease treatment as it does not possess the necessary activity against Borrelia burgdorferi. Overall, doxycycline is the most effective and widely recommended choice for treating Lyme disease in adults.