What is the first line treatment for Malaria that is chloroquine-sensitive?

Chloroquine is the first-line treatment for malaria caused by Plasmodium species that are sensitive to chloroquine. This medication works by interfering with the parasite's ability to digest hemoglobin, disrupting its metabolism and leading to its death.

When used for chloroquine-sensitive malaria, it is highly effective, safe, and generally well-tolerated, making it a cornerstone in the treatment of this specific form of malaria. The effectiveness of chloroquine hinges on the sensitivity of the malaria strain; therefore, it is primarily utilized in regions where the malaria strains have not developed resistance to the drug.

In contrast, other treatments may be more appropriate for different situations, such as severe cases or resistant strains. Artemisinin-based Combination Therapy is recommended for resistant strains and severe malaria but not first-line for chloroquine-sensitive cases. Atovaquone-Proguanil is also effective but is typically reserved for cases where chloroquine is not suitable or in areas with resistance. Quinine is mainly used for severe malaria cases and is not considered first-line treatment for uncomplicated, chloroquine-sensitive malaria.

Therefore, chloroquine remains the first-line treatment in cases of malaria where the strain is confirmed to be sensitive to the medication, allowing for effective management of the disease.