What is the first-line prophylactic treatment for post-exposure rabies?

The first-line prophylactic treatment for post-exposure rabies consists of administering both rabies vaccination and rabies immune globulin. This combination is crucial because it activates the immune system effectively against the rabies virus.

Rabies immune globulin provides immediate passive immunity by supplying the body with pre-formed antibodies against the rabies virus. This is vital for rapid response to a potential rabies exposure, particularly during the window before the active immune response to the vaccine can develop.

The rabies vaccination, on the other hand, serves as the active component of the prophylactic treatment. It stimulates the body to produce its own antibodies against rabies, thereby providing long-term immunity. The vaccine works best when given as soon as possible after exposure.

The inclusion of both components ensures a comprehensive approach to prevent the virus from causing the disease, which is nearly always fatal once symptoms develop. The other options listed do not provide the same combined efficacy, as some may lack immediate protection or fail to elicit a sufficient immune response.